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Contraindicated (one)pentobarbital decreases levels of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration with powerful CYP3A4 inducers; these medicines cut down exposure to vandetanib by as many as forty%.Pentobarbital also is effective by inhibiting glutamate, that is to blame for